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The Beauty of Protein Structures and the Mathematics behind Structural Bioinformatics Providing the framework for a one-semester undergraduate course, Structural Bioinformatics: An Algorithmic Approach shows how to apply key algorithms to solve problems related to macromolecular structure. Helps Students Go Further in Their Study of Structural Biology Following some introductory material in the first few chapters, the text solves the longest common subsequence problem using dynamic programming and explains the science models for the Nussinov and MFOLD algorithms. It then reviews sequence alignment, along with the basic mathematical calculations needed for measuring the geometric properties of macromolecules. After looking at how coordinate transformations facilitate the translation and rotation of molecules in a 3D space, the author introduces structural comparison techniques, superposition algorithms, and algorithms that compare relationships within a protein. The final chapter explores how regression and classification are becoming more useful in protein analysis and drug design. At the Crossroads of Biology, Mathematics, and Computer Science Connecting biology, mathematics, and computer science, this practical text presents various bioinformatics topics and problems within a scientific methodology that emphasizes nature (the source of empirical observations), science (the mathematical modeling of the natural process), and computation (the science of calculating predictions and mathematical objects based on mathematical models).

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Providing an introduction of the biological principles of the causes and treatment of cancer, this book covers key topics in cancer biology. It is useful for students of cell biology, biochemistry, molecular biology, genetics and biomedical sciences, and postgraduate students moving into cancer research.

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Biology of Sex PDF Download. Download free ebook of Biology of Sex in PDF format or read online by Alex Mills 9781487593377 Published on 2018-06-22 by University of Toronto Press

This text explains the biological aspects of human sex by using direct and intriguing comparisons with the many variations in sexual systems among non-human organisms.

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Evolutionary Bioinformatics PDF Download. Download free ebook of Evolutionary Bioinformatics in PDF format or read online by Rob DeSalle,Jeffrey Rosenfeld Published on 2013 by Garland Pub

Phylogenomics: A Primer is for advanced undergraduate and graduate biology students studying molecular biology, comparative biology, evolution, genomics, and biodiversity. It explores the origins of organic life on the planet, examines the use of scientific databases to understand the function of proteins within organisms, and provides insight into the interpretation of linear sequence information in the context of organismal change. This book explains the essential concepts underlying the storage and manipulation of genomics level data, construction of phylogenetic trees, population genetics, natural selection, the tree of life, DNA barcoding, and metagenomics. The inclusion of problem-solving exercises in each chapter provides students with a solid grasp of the important molecular and evolutionary questions facing modern biologists as well as the tools needed to answer them. Online exercises are also available to assist students in working with the programs and databases used to analyze phylogenomic data.

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Bioinformatics : A Primer PDF Download. Download free ebook of Bioinformatics : A Primer in PDF format or read online by P. Narayanan 9788122416107 Published on 2006-01-01 by New Age International

Bioinformatics Is The Bridge Between Experimental Data In Diverse Biologically Related Disciplines And Extrapolation Of Information, By Computational Analysis, About How The Systems And Processes Function. The Central Aims Are : (I) Elucidation (By Experimental Methods) Of Structural Features Of The Biological Entities (Proteins, Nucleic Acids Etc.), (Ii) Application Of Computational Tools And Approaches To Study Of Information Content, Organization, And Processing In Biological Systems, (Iii) Application Of Medical And Health Data At The Molecular Level (Biomedinformatics), Annotation Of Structural And Chemical Characteristics In Molecular And Drug Design (Cheminformatics). Thus, It Requires Trans-Disciplinary Collaboration Between Biophysicists, Drug Chemists, Molecular Biologists, Biomedical And Computer-Aided Modeling Experts.Acquisition Of High-Throughput Biological Data (E.G. From The Genomic Projects) At Fast Rate Has Ushered In Computer-Intensive Data Analysis (In Silico Analysis). But, Considerable Algorithmic Complexity Of Biological Systems Requires A Vast Of Amount Of Detailed Information (Experimental And Computational) At The Cellular And Molecular Levels For Their Complete Description. Therefore, There Is A Need For Books In This Subject With Due Emphasis On Both Experimental As Well As Computational Aspects.With These Broad Objectives In Mind, The Material Contents Of This Book Are Organized Under-Molecular Biophysics, Experimental Methods Of Structure Elucidation, Database Search, Data Mining And Analysis, Computational Methods Of Structure Prediction, And Rational Molecular/Drug Design (Molecular Engineering) And Validation-, With Easy Interface Between These Areas And Various Chapters. Ample Tables And Figures Are Intended To Facilitate The Readers An Insight To The Structure-Function Features At The Molecular Level. Exercise Modules And Bibliography For Each Chapter, And Glossary Are Aimed At Providing The Reader Wider Perception And Insight To The Subject Matter, And Scientific And Technical Terms. Index Is Provided To Help An Easy Access To The Words And Topics To The Subject Matter.

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Biophysical Tools for Biologists PDF Download. Download free ebook of Biophysical Tools for Biologists in PDF format or read online by John J. Correia,H. William Detrich, III Published on 2008-11-17 by Academic Press

Driven in part by the development of genomics, proteomics, and bioinformatics as new disciplines, there has been a tremendous resurgence of interest in physical methods to investigate macromolecular structure and function in the context of living cells. This volume in Methods in Cell Biology is devoted to biophysical techniques in vivo and their applications to cellular biology. Biophysical Tools for Biologists covers methods-oriented chapters on fundamental as well as cutting-edge techniques in molecular and cellular biophysics. This book is directed toward the broad audience of cell biologists, biophysicists, pharmacologists, and molecular biologists who employ classical and modern biophysical technologies or wish to expand their expertise to include such approaches. It will also interest the biomedical and biotechnology communities for biophysical characterization of drug formulations prior to FDA approval. Describes techniques in the context of important biological problems Delineates critical steps and potential pitfalls for each method

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Biophysical Techniques in Drug Discovery PDF Download. Download free ebook of Biophysical Techniques in Drug Discovery in PDF format or read online by Angeles Canales 9781782627333 Published on 2017-11-20 by Royal Society of Chemistry

Biophysical techniques are used in many key stages of the drug discovery process including in screening for new receptor ligands, in characterising drug mechanisms, and in validating data from biochemical and cellular assays. This book provides an overview of the biophysical methods applied in drug discovery today, including traditional techniques and newer developments. Perspectives from academia and industry across a spectrum of techniques are brought together in a single volume. Small and biotherapeutic approaches are covered and strengths and limitations of each technique are presented. Case studies illustrate the application of each technique in real applied examples. Finally, the book covers recent developments in areas such as electron microscopy with discussions of their possible impact on future drug discovery. This is a go-to volume for biophysicists, analytical chemists and medicinal chemists providing a broad overview of techniques of contemporary interest in drug discovery.

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Biophysics PDF Download. Download free ebook of Biophysics in PDF format or read online by Patrick F. Dillon 9781139504621 Published on 2012-01-19 by Cambridge University Press

Specifically tailored to life science students, this textbook explains quantitative aspects of human biophysics with examples drawn from contemporary physiology, genetics and nanobiology. It outlines important physical ideas, equations and examples at the heart of contemporary physiology, along with the organization necessary to understand that knowledge. The wide range of biophysical topics covered include energetics, bond formation and dissociation, diffusion and directed transport, muscle and connective tissue physics, fluid flow, membrane structure, electrical properties and transport, pharmacokinetics and system dynamics and stability. Enabling students to understand the uses of quantitation in modern biology, equations are presented in the context of their application, rather than derivation. They are each directed toward the understanding of a biological principle, with a particular emphasis on human biology. Supplementary resources, including a range of test questions, are available at www.cambridge.org/9781107001442.

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An indispensable tool for biology teacher educators, researchers, graduate students, and practising teachers, this book presents up-to-date research, addresses common misconceptions, and discusses the pedagogical content knowledge necessary for effective teaching of key topics in biology. Chapters cover core subjects such as molecular biology, genetics, ecology, and biotechnology, and tackle broader issues that cut across topics, such as learning environments, worldviews, and the nature of scientific inquiry and explanation. Written by leading experts on their respective topics from a range of countries across the world, this international book transcends national curricula and highlights global issues, problems, and trends in biology literacy.

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Proceedings of the 4th Asia-Pacific Bioinformatics Conference PDF Download. Download free ebook of Proceedings of the 4th Asia-Pacific Bioinformatics Conference in PDF format or read online by Tao Jiang 9781860946233 Published on 2006 by

High-throughput sequencing and functional genomics technologies have given us a draft human genome sequence and have enabled large-scale genotyping and gene expression profiling of human populations. Databases containing large numbers of sequences, polymorphisms, and gene expression profiles of normal and diseased tissues in different clinical states are rapidly being generated for human and model organisms. Bioinformatics is thus rapidly growing in importance in the annotation of genomic sequences, in the understanding of the interplay between genes and proteins, in the analysis of the genetic variability of species, and so on. This proceedings contains an up-to-date exchange of knowledge, ideas, and solutions to conceptual and practical issues of bioinformatics, by researchers, professionals, and industrial practitioners at the 4th Asia-Pacific Bioinformatics Conference held in Taipei in February 2006.

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Advances in Bioinformatics and Computational Biology PDF Download. Download free ebook of Advances in Bioinformatics and Computational Biology in PDF format or read online by Katia S. Guimarães,Anna Panchenko,Teresa M. Przytycka 9783642032233 Published on 2009-07-30 by Springer Science & Business Media

This volume contains the papers selected for presentation at the 4th Brazilian Sym- sium on Bioinformatics, BSB 2009, which was held in Porto Alegre, Brazil, during August 29–31, 2009. The BSB symposium had its origins in the Brazilian Workshop on Bioinformatics (WOB). WOB had three editions, in 2002 (Gramado, RS), in 2003 (Macaé, RJ), and in 2004 (Brasília, DF). The change in the designation from wo- shop to symposium reflects the increase in the quality of the contributions and also in the interest of the scientific community for the meeting. The previous editions of BSB took place in São Leopoldo, RS, in 2005, in Angra dos Reis, RJ, in 2007, and in Santo André, SP, in 2008. As evidence of the internationalization of the event, BSB 2009 had 55 submissions from seven countries. Of the 55 papers submitted, 36 were full papers, with up to 12 pages each, and 19 were extended abstracts, with up to 4 pages each. The articles submitted were carefully reviewed and selected by an international Program Comm- tee, comprising three chairs and 45 members from around the world, with the help of 21 additional reviewers. The Program Committee Chairs are very thankful to the - thors of all submitted papers, and especially to the Program Committee members and the additional reviewers, who helped select the 12 full papers and the six extended abstracts that make up this book.

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Bioinformatics PDF Download. Download free ebook of Bioinformatics in PDF format or read online by Andrzej Polanski,Marek Kimmel 9783540241669 Published on 2007-04-19 by Springer Science & Business Media

This textbook presents mathematical models in bioinformatics and describes biological problems that inspire the computer science tools used to manage the enormous data sets involved. The first part of the book covers mathematical and computational methods, with practical applications presented in the second part. The mathematical presentation avoids unnecessary formalism, while remaining clear and precise. The book closes with a thorough bibliography, reaching from classic research results to very recent findings. This volume is suited for a senior undergraduate or graduate course on bioinformatics, with a strong focus on mathematical and computer science background.

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Artificial Intelligence Safety and Security PDF Download. Download free ebook of Artificial Intelligence Safety and Security in PDF format or read online by Roman V. Yampolskiy 9781351251365 Published on 2018-07-27 by CRC Press

The history of robotics and artificial intelligence in many ways is also the history of humanity’s attempts to control such technologies. From the Golem of Prague to the military robots of modernity, the debate continues as to what degree of independence such entities should have and how to make sure that they do not turn on us, its inventors. Numerous recent advancements in all aspects of research, development and deployment of intelligent systems are well publicized but safety and security issues related to AI are rarely addressed. This book is proposed to mitigate this fundamental problem. It is comprised of chapters from leading AI Safety researchers addressing different aspects of the AI control problem as it relates to the development of safe and secure artificial intelligence. The book is the first edited volume dedicated to addressing challenges of constructing safe and secure advanced machine intelligence. The chapters vary in length and technical content from broad interest opinion essays to highly formalized algorithmic approaches to specific problems. All chapters are self-contained and could be read in any order or skipped without a loss of comprehension.

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General Biophysics PDF Download. Download free ebook of General Biophysics in PDF format or read online by M. V. Volkenstein 9781483265391 Published on 2013-10-22 by Academic Press

General Biophysics, Volume II studies biological phenomena at the supramolecular and cellular levels of structure. The book considers biological phenomena on the basis of general physical principles. The text presents topics on bioenergetic processes; structure and properties of mitochondria; photo-biological processes; nonlinear dynamic processes; and physical interpretation of the most general problems of biology. Graduate and postgraduate students in the field of physical and life sciences will find this book very useful.

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Book which was published by Academic Press since 2013-10-22 have ISBNs, ISBN 13 Code is 9781483265391 and ISBN 10 Code is 1483265390

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Radiation Biophysics PDF Download. Download free ebook of Radiation Biophysics in PDF format or read online by Edward L. Alpen 9780080540207 Published on 1997-10-22 by Academic Press

This newly revised and updated edition of Radiation Biophysics provides an in-depth description of the physics and chemistry of radiation and its effects on biological systems. Coverage begins with fundamental concepts of the physics of radiation and radioactivity, then progresses through the chemistry and biology of the interaction of radiation with living systems. The Second Edition of this highly praised text includes major revisions which reflect the rapid advances in the field. New material covers recent developments in the fields of carcinogenesis, DNA repair, molecular genetics, and the molecular biology of oncogenes and tumor suppressor genes. The book also includes extensive discussion of the practical impact of radiation on everyday life. Covers the fundamentals of radiation physics in a manner that is understandable to students and professionals with a limited physics background Includes problem sets and exercises to aid both teachers and students Discusses radioactivity, internally deposited radionuclides, and dosimetry Analyzes the risks for occupational and non-occupational workers exposed to radiation sources

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Book which was published by Academic Press since 1997-10-22 have ISBNs, ISBN 13 Code is 9780080540207 and ISBN 10 Code is 0080540201

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The Emergence of Life PDF Download. Download free ebook of The Emergence of Life in PDF format or read online by Pier Luigi Luisi 9781139455640 Published on 2006-07-13 by Cambridge University Press

The origin of life from inanimate matter has been the focus of much research for decades, both experimentally and philosophically. Luisi takes the reader through the consecutive stages from prebiotic chemistry to synthetic biology, uniquely combining both approaches. This book presents a systematic course discussing the successive stages of self-organisation, emergence, self-replication, autopoiesis, synthetic compartments and construction of cellular models, in order to demonstrate the spontaneous increase in complexity from inanimate matter to the first cellular life forms. A chapter is dedicated to each of these steps, using a number of synthetic and biological examples. With end-of-chapter review questions to aid reader comprehension, this book will appeal to graduate students and academics researching the origin of life and related areas such as evolutionary biology, biochemistry, molecular biology, biophysics and natural sciences.

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Book which was published by Cambridge University Press since 2006-07-13 have ISBNs, ISBN 13 Code is 9781139455640 and ISBN 10 Code is 1139455648

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Computational Approaches to Protein Dynamics PDF Download. Download free ebook of Computational Approaches to Protein Dynamics in PDF format or read online by Monika Fuxreiter 9781482297867 Published on 2014-12-24 by CRC Press

The Latest Developments on the Role of Dynamics in Protein Functions Computational Approaches to Protein Dynamics: From Quantum to Coarse-Grained Methods presents modern biomolecular computational techniques that address protein flexibility/dynamics at all levels of theory. An international contingent of leading researchers in chemistry, physics, and biology show how these advanced methods provide insights into dynamic aspects of biochemical processes. A particular focus is on intrinsically disordered proteins (IDPs), which lack a well-defined three-dimensional structure and function as dynamic ensembles. The book covers a wide spectrum of dynamics, from electronic structure-based to coarse-grained techniques via multiscaling at different levels. After an introduction to dynamics and historical overview of basic methodologies, the book addresses the following issues: Is there a quantitative relationship between enzymatic catalysis and protein dynamics? Which are the functionally relevant motions of proteins? How can structural properties and partner recognition mechanisms of IDPs be simulated? How can we speed up molecular dynamics? How can we describe conformational ensembles by the synergistic effort of computations and experiments? While dynamics is now considered essential for interpreting protein action, it is not yet an integral component in establishing structure–function relationships of proteins. Helping to reshape this classical view in biochemistry, this groundbreaking book explores advances in computational methodology and contributes to the new, ensemble way of studying proteins.

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Computational Biophysics of Membrane Proteins PDF Download. Download free ebook of Computational Biophysics of Membrane Proteins in PDF format or read online by Carmen Domene 9781782624905 Published on 2016-12-05 by Royal Society of Chemistry

Exploring current themes in modern computational and membrane protein biophysics, this book is ideal for researchers in computational chemistry and computational biophysics.

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Biophysics PDF Download. Download free ebook of Biophysics in PDF format or read online by C. Sybesma 9789400922396 Published on 2012-12-06 by Springer Science & Business Media

Today, courses on biophysics are taught in almost all universities in the world, often in separate biophysics departments or divisions. This reflects the enormous growth of the field, even though the problem of its formal definition remains unsettled. In spite of this lack of definition, biophysics, which can be considered as an amalgamation of the biological and the physical sciences, is recognized as a major scientific activity that has led to spectacular developments in biology. It has increased our knowledge of biological systems to such an extent that even industrial and commercial interests are now beginning to put their stamps on biological research. A major part of these developments took place during the last two decades. Therefore, an introductory textbook on biophysics that was published a dozen years ago (c. Sybesma, An Introduction to Biophysics, Academic Press, 1977) no longer could fulfil | ... the need for a comprehensive but elementary textbook ... -| (R. Cammack, Nature 272 (1978), 96). However, because of the increased proliferation of biophysics into higher education, the need for introductory course texts on biophysics is stronger than ever. This fact, together with valuable comments of many readers, have encouraged me to revise the original book.

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