Applied Biophysics for Drug Discovery PDF Download. Download free ebook of Applied Biophysics for Drug Discovery in PDF format or read online by Donald Huddler,Edward E. Zartler 9781119099505 Published on 2017-07-14 by John Wiley & Sons
Applied Biophysics for Drug Discovery is a guide to new techniques and approaches to identifying and characterizing small molecules in early drug discovery. Biophysical methods are reasserting their utility in drug discovery and through a combination of the rise of fragment-based drug discovery and an increased focus on more nuanced characterisation of small molecule binding, these methods are playing an increasing role in discovery campaigns. This text emphasizes practical considerations for selecting and deploying core biophysical method, including but not limited to ITC, SPR, and both ligand-detected and protein-detected NMR. Topics covered include: • Design considerations in biophysical-based lead screening • Thermodynamic characterization of protein-compound interactions • Characterizing targets and screening reagents with HDX-MS • Microscale thermophoresis methods (MST) • Screening with Weak Affinity Chromatography • Methods to assess compound residence time • 1D-NMR methods for hit identification • Protein-based NMR methods for SAR development • Industry case studies integrating multiple biophysical methods This text is ideal for academic investigators and industry scientists planning hit characterization campaigns or designing and optimizing screening strategies.
This Book was ranked at 38 by Google Books for keyword Biophysics.
Book ID of Applied Biophysics for Drug Discovery's Books is oOMsDwAAQBAJ, Book which was written by Donald Huddler,Edward E. Zartler have ETAG "3Dll8+315s4"
Book which was published by John Wiley & Sons since 2017-07-14 have ISBNs, ISBN 13 Code is 9781119099505 and ISBN 10 Code is 1119099501
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Download Applied Biophysics for Drug Discovery PDF Free
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Download Applied Biophysics for Drug Discovery PDF
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