Molecular Biophysics of the Extracellular Matrix PDF Download. Download free ebook of Molecular Biophysics of the Extracellular Matrix in PDF format or read online by Struther Arnott,D. A. Rees,E. R. Morris Published on 1984-10-19 by Springer Science & Business Media
Biopolymers, such as proteins and nucleic acids have been subjected to a rational succession of structural studies in which the determination of chemical compositions, link\u00ad ages, and sequences is followed by investigations of molecu\u00ad lar architecture and interactions. By the end of the 1960s the covalent structures of glycosaminoglycans and proteo\u00ad glycans had been defined both within the carbohydrate chains and in respect to their linkages to protein. The scene was therefore set for successful probing of three\u00ad dimensional shapes and intermolecular associations. For\u00ad tunately, during the 1970s appropriate physical methods were themselves greatly increasing in power. Consequently much progress has been made using X-ray diffraction anal\u00ad ysis of hydrated films, nuclear magnetic resonance spectro\u00ad scopy, and chromatographie methods for investigation of molecular interactions in solution. We now have a great deal of information about molecular shapes, their sensitiv\u00ad ity to environment (especially associated cations), and their modes of interaction that could be relevant to super\u00ad molecular assemblies in biological milieux. For these rea\u00ad sons we judged that it would be timely to distil the main conclusions from this phase of research to prepare for the next, which will involve detailed study of the interplay be\u00ad tween biological function and molecular structure. The idea for this volume emerged from a workshop meeting at Colworth sponsored by the Biochemical Society.
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